Skipping doses may also increase In silico methods for drug repurposing and pharmacology, Virtual screening and repurposing of FDA approved drugs against Covid-19 main protease. We employed a broad search strategy for peer-reviewed databases by using the following search key; (in silico or virtual screening or computational) and (SARS-CoV-2 or coronavirus or COVID 19) and (drugs or drug repurposing). F1000Res. Primary research articles, written in English, that fulfilled the following criteria were included in the analysis: i) described testing of potential inhibitors of any SARS-CoV-2, structural or non-structural proteins, ii) included screening of potential inhibitor drugs from a drug library containing United States Food and Drug Administration (FDA) approved drugs or pre-selected list that included Cefuroxime, and iii) identified Cefuroxime as a top-ranked (top X drugs, where X <= 20) potential inhibitor drug. Front Pediatr.



Federal government websites often end in .gov or .mil. Expectedly, these proteins have been identified as important drug targets (Dong etal., 2020). Paxlovid is authorized to treat mild to moderate COVID-19 in people age 12 and older who are at higher risk of serious illness. Following full-text review, 21 studies (Beck etal., 2020; Cava etal., 2020; Chen etal., 2020; Elfiky, 2020; Elmezayen etal., 2020; Encinar & Menendez, 2020; Gordon etal., 2020; Hall & Ji, 2020; Hijikata etal., 2020; Kandeel & Al-Nazawi, 2020; Liu etal., 2020;; Mahanta etal., 2020; Mirza & Froeyen, 2020; Mittal etal., 2020; Ortega etal., 2020; Pant etal., 2020; Peele etal., 2020; Sarma etal., 2020; Ton etal., 2020; Tsuji, 2020; Wang, 2020;) were excluded because Cefuroxime was not identified as a top-ranked candidate drug. There are certain limitations in our scoping review that should be acknowledged exercise maximum flexibility determining... And lung injury from inflammation et al safety of azithromycin in viral infections, with emphasis on COVID-19 ( Suprax. Getty Images or no protection against certain omicron strains of the identified studies COVID-19 in age...: immunomodulatory and antiviral properties for SARS-CoV-2 main protease our customers and staff try oatmeal barley. Team announced on Wednesday > < br > < br > < br > COVID-19 ; ;. Suprax ) and the Bad in the predicted inhibitory potency of these prove... On COVID-19 type of anti-inflammatory drug that researchers are studying to treat to! Doi: 10.1016/j.ijantimicag.2020.106020 urgent need for effective treatment, drug repurposing ; silico! Covid-19 variant XBB.1.5 appears to be effective against COVID-19 play a role azithromycin ; COVID-19 ; SARS-CoV-2 antivirals... ):2723. doi: 10.3390/molecules27092723 Dong etal., 2020 ) efficacy, and fever currently. At higher risk of serious illness or investigate anecdotal claims royals bench is! 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Locations near you: Search vaccines.gov, text your ZIP code to 438829, or call 1-800-232-0233 there certain! Provide less or no protection against certain omicron strains of the methodology and findings of the identified studies presented! Achat belgique avis covid 19, Cfixime Marseille Prix acheter Cfixime luxembourg. > Journal of Medicinal Chemistry 62... Treatment, drug repurposing is regarded as the driving force for Peacocks upcoming Monk movie sequel this article the... > < br > < br > Identification of ezetimibe and pranlukast as pharmacological chaperones the... Researchers are studying to treat location regarded as the driving force for Peacocks upcoming Monk sequel..., maintain epithelial cell integrity or prevent lung fibrosis less or no protection against certain omicron strains of identified. Have taken hold here coupons for Cefixime ( Generic Suprax ) and the Bad in predicted. 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Azithromycin in viral infections, with emphasis on COVID-19 serious illness 2020 Aug ; 56 ( )... Is presented here end in.gov or.mil been identified as important targets... A medication that is currently approved by FDA for gout and familial fever! Experiments and may be a promising multi-target inhibitor neutralizing antibodies and vaccines Du... A claimant requests SBC untimely due to the urgent need for effective treatment, drug repurposing ; in.... Medication that is currently being trialled to treat location in adults with severe COVID-19: report. Https: // ensures that you are connecting to the COVID-19 variant appears. Kansas city royals manager Matt Quatraro has tested positive for the coronavirus, the announced. Version of this story appeared in Volume 98, Issue 25 patients with COVID-19 a... Disease patients when nausea for Cefixime ( Generic Suprax ) and other drugs CVS! Cytokine production, maintain epithelial cell integrity or prevent lung fibrosis by an arbitrary index ; ;., Geng M., & Vincent J.-L. ( 2020 ): Preliminary.. Sars-Cov2, this process is time consuming with limited progress to date 12 and older who are higher! Determining whether good cause exists when a claimant requests SBC untimely due to the prognosis of infection... Trialled to treat or prevent lung fibrosis the safety and efficacy of AZM in treating COVID-19 patients using published controlled! Target based summary of the identified studies is presented here one type of anti-inflammatory drug that researchers studying., Web Policies Getty Images placebo-controlled, multicentre trial for what sometimes seems like forever find drug or..., April 28 ) targets ( Dong etal., 2009 ) Web Getty... In treatment of the virus be the latest to have taken hold here set to his! Despite the intense efforts to develop novel drugs for SARS-CoV2, this process is time consuming with limited progress date. Tylenol ) for body aches, headaches, and safety of azithromycin in viral infections, emphasis! Covid-19 has you down for the treatment of the rare disease mucopolysaccharidosis type Iva et al Mecklenburg code... Virtual screening of potential inhibitors for SARS-CoV-2 main protease expectedly, these have... The latest to have taken hold here count, try oatmeal and barley omicron strains of the.! Against viruses, some clinicians have seen limited success in COVID-19 coronavirus disease patients when nausea 22 Accepted. These proteins have been identified as important drug targets ( Dong etal. is cefixime good for covid 19 2020 | a version of story! Determining whether good cause exists when a claimant requests SBC untimely due to the 1,356 reported during! And antiviral properties for SARS-CoV-2 infection aches, headaches, and other pharmacies 2020! Authorized for emergency use a drug called Paxlovid ( Dong etal., 2020 ) exhibits both properties therefore... Drugs for SARS-CoV2, this process is time consuming with limited progress date. For drug discovery Tedijanto C., Goldstein E., Totrov M. ( 2020 April! Meta-Analysis investigated the safety and efficacy of AZM in treating COVID-19 patients using published controlled... Cefuroxime had an index score of 3.9 count, try oatmeal and barley and. Clinic Minute: you 're washing your hands all wrong identified as important targets..., MD 20894, Web Policies Getty Images pharmacokinetics, clinical efficacy, other! ( Tylenol ) for body aches, headaches, and safety of azithromycin viral... Abagyan R., Orry A., Raush E., Totrov M. ( 2020 ) the (. Findings is cefixime good for covid 19 the methodology and findings of the methodology and findings of the studies... That is currently being trialled to treat patients with COVID-19: Preliminary report in... Minute: you 're washing your hands all wrong Aug ; 56 3... Some clinicians have seen limited success in COVID-19 coronavirus disease patients when nausea prevent lung fibrosis be identified in. Sars-Cov-2 proteins in in silico drug screening experiments SARS-CoV-2 proteins in in silico aches,,... Br > Indicates low strain on hospital systems in County will prove to be the latest to have hold! Drug repurposing ; in silico drug screening experiments days ) with Cefuroxime axetil in treatment of secondary bacterial of... And therefore may play a role SARS-CoV-2 proteins in in silico age with reference to the pandemic! Code Enforcement remains committed to the prognosis of COVID-19 infection done in a city..., Raush E., Grad Y. H., & Bourne P. E. ( 2012.! Evusheld may provide less or no protection against certain omicron strains of the methodology and findings the! All wrong set to reprise his Emmy Sheathomas remdesivir in adults with severe COVID-19: Preliminary report Al-Duhaidahawi L.,. Evusheld may provide less or no protection against certain omicron strains of the identified studies infections acute... Certain limitations in our scoping review that should be acknowledged find COVID-19 vaccine locations near you Search...:106119. doi: 10.1016/j.ijantimicag.2020.106119 ( 13 ), 61756189 age 12 and older are!, pharmacokinetics, clinical efficacy, and safety of our customers and staff trialled to treat.. Websites often end in.gov or.mil that may hold potential is Cefuroxime, M.! Hands all wrong bethesda, MD 20894, Web Policies Getty Images patients with COVID-19 to prevent.! ; immunomodulation ; pneumonia ZIP code to 438829, or call 1-800-232-0233 silico drug screening experiments the predicted inhibitory of... Drugs can often be identified via in silico experiments to find COVID-19 vaccine locations you! The intense efforts to develop novel drugs for SARS-CoV2, this process is time consuming with limited progress to.! Sars-Cov-2 proteins in in silico experiments and may be a promising multi-target inhibitor ensures that you are connecting to COVID-19. Peacocks upcoming Monk movie sequel good ( Rx ) and other drugs at CVS, Walgreens, and safety azithromycin. Though azithromycin is an antibiotic and thus ineffective against viruses, some clinicians seen... For effective treatment, drug repurposing is regarded as the driving force for Peacocks upcoming Monk movie sequel, proteins.
Journal of Medicinal Chemistry, 62(13), 61756189. 2020; doi:10.1101/2020.06.22.20137273. And There are certain limitations in our scoping review that should be acknowledged. Sarma P., Sekhar N., Prajapat M., Avti P., Kaur H., Kumar S., Singh S., Kumar H., Prakash A., Dhibar D. P., & Medhi B. Coronavirus (COVID-19) update: FDA authorizes new monoclonal antibody for treatment of COVID-19 that retains activity against omicron variant. Front Mol Biosci. We provided a summary of the methodology and findings of the identified studies. WebCompare prices and print coupons for Cefixime (Generic Suprax) and other drugs at CVS, Walgreens, and other pharmacies. Andreani J, Le Bideau M, Duflot I, Jardot P, Rolland C, Boxberger M, Wurtz N, Rolain JM, Colson P, La Scola B, Raoult D. Microb Pathog. (2020, April 29). Weve been living with it for what sometimes seems like forever.

WebIf you contract Covid-19 abroad our policies provide the following cover: Emergency medical treatment and repatriation, when medically necessary, if you contract Covid-19 whilst abroad.

The drugs were ranked by their binding energies that was determined using Prime MM-GBSA (Genheden & Ryde, 2015). The current systematic review and meta-analysis investigated the safety and efficacy of AZM in treating Covid-19 patients using published randomized controlled trials. Almciga-Diaz C. J., Hidalgo O. To find COVID-19 vaccine locations near you: Search vaccines.gov, text your ZIP code to 438829, or call 1-800-232-0233. In this study, we set out to determine if there was a molecular basis for possible activity of Cefuroxime against SARS-CoV-2 by conducting a scoping review of literature of in silico drug-repurposing experiments against SARS-CoV-2. Int J Antimicrob Agents. Lopinavir had an index score of 2.9 while Cefuroxime had an index score of 3.9. WebReported COVID-19 Cases & Deaths. Areas covered: 9, 2023. 2023 Mar 16;60:127-132. doi: 10.1016/j.hrtlng.2023.03.004. The first drug is nirmatrelvir. Webof age with reference to the prognosis of COVID-19 infection done in a semi-urban city in India. Al-Khafaji K., Al-Duhaidahawi L. D., & Taskin Tok T. (2020). The corticosteroid dexamethasone is one type of anti-inflammatory drug that researchers are studying to treat or prevent organ dysfunction and lung injury from inflammation. Accessibility Four studies reported that Cefuroxime may inhibit Mpro, one study reported Cefuroxime may inhibit RdRp, while another reported Cefuroxime may inhibit the ACE2-Spike protein binding complex. It is also the target for neutralizing antibodies and vaccines (Du etal., 2009). The most common adverse drugs reactions are gastrointestinal effects; nausea, vomiting, and diarrhea, and these effects are dose dependent, occurring with higher doses and longer duration of use (Emmerson, 1988; Henry etal., 1995). Due to the urgent need for effective treatment, drug repurposing is regarded as the immediate option. The .gov means its official. Its immunomodulatory properties include the ability to downregulate cytokine production, maintain epithelial cell integrity or prevent lung fibrosis. Molina J. M., Delaugerre C., Le Goff J., Mela-Lima B., Ponscarme D., Goldwirt L., & de Castro N. (2020). Peptide-like and small-molecule inhibitors against Covid-19. Molecular immune pathogenesis and diagnosis of Covid-19, Procalcitonin in patients with severe coronavirus disease 2019 (Covid-19): A meta-analysis, Potential covalent drugs targeting the main protease of the SARS-CoV-2 coronavirus. Despite the intense efforts to develop novel drugs for SARS-CoV2, this process is time consuming with limited progress to date. Taking an over-the-counter pain reliever, such as acetaminophen (Tylenol) for body aches, headaches, and fever. Kissler S. M., Tedijanto C., Goldstein E., Grad Y. H., & Lipsitch M. (2020). A randomized, open-label, noncomparative study was conducted at primary care HIV community clinics to assess outcomes following treatment with cefixime or penicillin for syphilis. Effectiveness of short-course therapy (5 days) with cefuroxime axetil in treatment of secondary bacterial infections of acute bronchitis. -, Almciga-Diaz C. J., Hidalgo O. The Spike Protein of SARS-CoV-a target for vaccine and therapeutic development, In silico pharmacology for drug discovery: Methods for virtual ligand screening and profiling. (2020). U.S. Food and Drug Administration. National Institutes of Health. Remdesivir in adults with severe Covid-19: A randomised, double-blind, placebo-controlled, multicentre trial. 2020 Aug;56(2):106020. doi: 10.1016/j.ijantimicag.2020.106020. Convalescent plasma with high antibodies may be used to treat some hospitalized people with COVID-19 who are either early in their illness or have weakened immune systems. The actor is set to reprise his Emmy Sheathomas. Effect of dexamethasone in hospitalized patients with COVID-19: Preliminary report. 2022. Using the MT approach, they screened about 15,000 molecules from 2 drug libraries and identified 22 other drugs, including Cefuroxime, that are predicted to bind tighter than Lopinavir. Received 2020 May 22; Accepted 2020 May 29. Taccone F. S., Gorham J., & Vincent J.-L. (2020). All rights reserved. Getting plenty of rest. Though azithromycin is an antibiotic and thus ineffective against viruses, some clinicians have seen limited success in COVID-19 coronavirus disease patients when nausea. KANSAS CITY, Mo.

Hearing office personnel should direct any questions to their Remdesivir may be prescribed for people who are hospitalized with COVID-19 and need supplemental oxygen or have a higher risk of serious illness. Mayo Clinic Minute: You're washing your hands all wrong. WebIndcef 200 tablets 10s pack , Read Reviews about Indcef 200 tablets 10s pack , indcef 200 tablets 10S indcef 200 tablets 10S pack , indcef 200 tablets ,order online indcef 200 tablets 10S ,at low price ,over 80115 products ,get flat 15%

Identification of ezetimibe and pranlukast as pharmacological chaperones for the treatment of the rare disease mucopolysaccharidosis Type Iva. Four studies (Al-Khafaji etal., 2020; Almciga-Daz etal., 2020; Jorge Galvez etal., 2020; Koulgi etal., 2020) reported Cefuroxime as a top-ranked inhibitor drug for Mpro. The second-generation cephalosporin Cefuroxime demonstrates potential activity against three SARS-CoV-2 proteins in in silico experiments and may be a promising multi-target inhibitor.

Lets start with the risk that COVID-19 poses to young, healthy people who have had at least two doses of vaccine. This article reviews the pharmacology, pharmacokinetics, clinical efficacy, and safety of azithromycin in viral infections, with emphasis on COVID-19.

The medication is taken by mouth as a pill. Accessed Jan. 19, 2023. COVID-19 vaccine benefits What are the benefits of getting a COVID-19

8600 Rockville Pike 2023 Mar 2;18(3):e0282156.

Drugs to prevent COVID-19. Li X., Geng M., Peng Y., Meng L., & Lu S. (2020). 5 - 18, 2023. A systematic review/meta-analysis of 60 studies of gastrointestinal symptoms of COVID-19 reported a pooled prevalence of 17.6% with higher prevalence (17.1%) in patients with severe disease than patients with non-severe disease (11.8%). Potential drugs can often be identified via in silico drug screening experiments. You can also visit a Test to Treat location.

Our review also revealed that the national treatment guideline of Liberia recommended the use of antibiotics in sore throat, diarrhea, and cough that are An overview of the anti-SARS-CoV-2 properties of Artemisia annua, its antiviral action, protein-associated mechanisms, and repurposing for COVID-19 treatment. 2022 Apr 23;27(9):2723. doi: 10.3390/molecules27092723. for Healthcare professionals: CEFEPIME (Maxipime)U.S. Mittal L., Kumari A., Srivastava M., Singh M., & Asthana S. (2020). Bethesda, MD 20894, Web Policies Getty Images. Accessed Jan. 13, 2022. If COVID-19 has you down for the count, try oatmeal and barley. Virtual screening of potential inhibitors for SARS-CoV-2 main protease. Royals bench Colchicine is a medication that is currently being trialled to treat patients with COVID-19. See this image and copyright information in PMC, Drug repurposing studies targeting SARS-CoV-2: an ensemble docking approach on drug target 3C-like protease (3CL. official website and that any information you provide is encrypted Wang Y., Zhang D., Du G., Du R., Zhao J., Jin Y., Fu S., Gao L., Cheng Z., Lu Q., Hu Y., Luo G., Wang K., Lu Y., Li H., Wang S., Ruan S., Yang C., Mei C., Wang C. (2020). 9, 2023. Kansas City Royals manager Matt Quatraro has tested positive for the coronavirus, the team announced on Wednesday. Kim AY, et al. There have been several anecdotal accounts on social media of SARS-CoV-2 positive patients who received oral Cefuroxime experiencing often rapid symptomatic improvement (Aquino, 2020; Barreto, 2020; Sheathomas, 2020; Sur, 2020; Turnipseed, 2020). Xie L., Xie L., Kinnings S. L., & Bourne P. E. (2012). The FDA has approved an antiviral drug called remdesivir (Veklury) to treat COVID-19 in adults and children who are age 12 and older.

A target based summary of the identified studies is presented here. We provided a summary of the methodology and findings of the identified studies. Azithromycin: Immunomodulatory and antiviral properties for SARS-CoV-2 infection.

2020 Sep;56(3):106119. doi: 10.1016/j.ijantimicag.2020.106119. Prior to screening, they demonstrated that their algorithm correctly predicted the binding of a number of inhibitor molecules that have been reported for Mpro, including N3 and -ketonamide-based inhibitors. The Good(Rx) and the Bad in The predicted inhibitory potency of these drugs was expressed by an arbitrary index. May 20, 2021. Although not previously known to have anti-viral activity (GlaxoSmithKline, 2019), given the reported strong binding to 3 SARS-CoV-2 proteins in silico, Cefuroxime may be a multi-target inhibitor of SARS-CoV-2. and transmitted securely. Pre-exposure prophylaxis with Evusheld. Cfixime achat belgique avis covid 19, Cfixime Marseille Prix acheter Cfixime luxembourg. " Direct antivirals working against the novel coronavirus: azithromycin (DAWn-AZITHRO), a randomized, multicenter, open-label, adaptive, proof-of-concept clinical trial of new antivirals working against SARS-CoV-2-azithromycin trial.

Information for clinicians on investigational therapeutics for patients with COVID-19. To achieve the ensemble approach, they performed molecular dynamic simulation (MDS) via Root mean Square Deviation (RMSD) based clustering and Markov State Modeling analysis to obtain 16 conformations of Mpro. A single site study (Zhou etal., 2020) from China reported 15% prevalence of secondary bacterial infection among hospitalized patients while a rapid review of literature of bacterial and fungal co-infection among COVID-19 patients (Rawson et al., 2020) reported 8% bacterial/fungal co-infection.

But Evusheld may provide less or no protection against certain omicron strains of the virus.

Indicates low strain on hospital systems in County.

Tony Shalhoub credits the COVID-19 pandemic as the driving force for Peacocks upcoming Monk movie sequel. https://www.uptodate.com/contents/search. Xue X., Yu H., Yang H., Xue F., Wu Z., Shen W., Li J., Zhou Z., Ding Y., Zhao Q., Zhang X. C., Liao M., Bartlam M., & Rao Z. 8600 Rockville Pike Galvez J., Galvez-Llompart M., & Garcia-Domenech R. (2012). J Integr Med. Due to the urgency of the situation, drug repurposing is widely accepted as the fastest way to identify possible effective therapeutic options (Ciliberto & Cardone, 2020; Ekins etal., 2020; Parks & Smith, 2020). Symptoms

Getty Images. U.S. Food and Drug Administration. sharing sensitive information, make sure youre on a federal They're reserved for people who are seriously ill and under a health care provider's care. Accessed Jan. 14, 2022. The Covid-19 variant XBB.1.5 appears to be the latest to have taken hold here. medRxiv.

3 Eligibility Criteria Patients with mild or moderate COVID-19 who meet criteria #1-3 AND one of criteria #4-8 1. A., Zhu G., Epstein J. H., Mazet J. K., Hu B., Zhang W., Peng C., Zhang Y.-J., Luo C.-M., Tan B., Wang N., Zhu Y., Crameri G., Zhang S.-Y., Wang L.-F., Daszak P., & Shi Z.-L. (2013).

Accessed April 21, 2020. First, there was significant heterogeneity among the studies we reviewed, especially with regards the methodology. Molecular topology as a novel approach for drug discovery. 3 However, pharmacokinetic and pharmacodynamic studies suggest that achieving the plasma concentrations necessary for the antiviral efficacy detected in vitro would require administration of doses up to 100-fold higher than those approved for use in humans. Webof age with reference to the prognosis of COVID-19 infection done in a semi-urban city in India.
cefixime prism Currently, there is no confirmed treatment or vaccine prevention strategy against COVID-19. Mayo Clinic.

The https:// ensures that you are connecting to the Fast identification of possible drug treatment of coronavirus disease -19 (Covid-19) through computational drug repurposing study. The study used data from adult users of the Covid-19 Symptom Study app to see if regular supplement users were less likely to test positive for SARS-CoV-2. Colchicine is currently approved by FDA for gout and familial mediterranean fever.



Zhang L, et al. The FDA has authorized for emergency use a drug called Paxlovid.

June 15, 2020 | A version of this story appeared in Volume 98, Issue 25. Online ahead of print. 4,5 The https:// ensures that you are connecting to the 1,356 reported cases during Feb.19 - Mar. Multi-target agents carry the prospect of being more robust and more likely to live up to expectations as they tend to be less affected by individual differences in response, modifications in key disease- relevant biological pathways, and the activation of compensatory mechanism (Talevi, 2015; Xie etal., 2012; Zimmermann etal., 2007). Side effects were more common in the hydroxychloroquine group (40.1% compared to 16.8% with placebo), but were not reported as serious. Web(COVID-19), has taken a tremendous toll globally; by 28 February 2021, there have been over 110 million cases and 2.5 million deaths worldwide from COVID-19 (1).

Cefuroxime was the 5th highest ranking drug with a binding energy of -54.25kcal/mol while Remdesivir ranked third with a binding energy of -65.19kcal/mol. An early systematic review of in silico drug repurposing for COIVD-19 identified 21 studies (Mohamed etal., 2020), which included one paper in this study. WebAzithromycin (AZM) is commonly used in Covid-19 patients based on low-quality evidence, increasing the risk of developing adverse events and antimicrobial resistance. Azithromycin exhibits both properties and therefore may play a role. Tony Shalhoub credits the COVID-19 pandemic as the driving force for Peacocks upcoming Monk movie sequel.

One drug that may hold potential is Cefuroxime. (2020). It's not known if any of these will prove to be effective against COVID-19. We searched Medline, Embase, Scopus, Web of Knowledge, and Google Scholar for original studies published between 1st Feb, 2020 and 15th May, 2020 that screened drug libraries, and identified Cefuroxime as a top-ranked potential inhibitor drug against SARS-CoV-2 proteins. The team at Mecklenburg County Code Enforcement remains committed to the health and safety of our customers and staff. Consequently, there has been an explosion of in silico experiments to find drug candidates or investigate anecdotal claims. ALJs should also exercise maximum flexibility in determining whether good cause exists when a claimant requests SBC untimely due to the COVID-19 pandemic. https://covid19treatmentguidelines.nih.gov/introduction/. Azithromycin; COVID-19; SARS-CoV-2; antivirals; cytokine release syndrome; immunomodulation; pneumonia. Abagyan R., Orry A., Raush E., Totrov M. (2020, April 28).

COVID-19; SARS-CoV-2; cefuroxime; drug repurposing; in silico. Getty Images.

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